Control age-related macular degeneration and diabetic retinopathy by topical
application of atorvastatin (ATS) using solid lipid nanoparticles (SLN) technology
An Ocular Formulation & a Method for its Preparation
Specifications of An Ocular Formulation
• Prolonged residence, up to 7 h of ATS-SLNs in eyes.
• Three-tier (in vitro, ex vivo, and in vivo) ocular safety, improved stability (13.62 times)
including photostability was established.
Applications of An Ocular Formulation
• Special application for treatment of posterior eye diseases including AMD and
diabetic retinopathy which are otherwise catered to by the invasive routes of
• ATS-SLNs are 8 and 12 times more bioavailable in aqueous and vitreous humor,
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