Process for preparing solid lipid nanoparticles as gene delivery vehicle; novel
encapsulation technique to increase bioavailability, efficacy, stability during manufacturing
and storage of biomolecules including siRNA.
Process for Encapsulating Macrobiomolecules in Solid Lipid Nanoparticles (201611003140)
Specifications of Process for Encapsulating Macrobiomolecules in Solid Lipid Nanoparticles
• A process for preparing a solid lipid nanoparticle efficiently entrapping a biomolecule
including genetic material within the lipid matrix protecting it against degradation, and
ensuring its intracellular uptake.
Applications of Process for Encapsulating Macrobiomolecules in Solid Lipid Nanoparticles
• Provide a simple, easily scalable, and commercially viable process for preparing solid
lipid nanoparticles as carriers for biomolecules
• Method ensures no or minimal thermal/enzymatic degradation of biomolecule
• Completely mask the high negative charge on the nucleic acids or genetic material and
produce solid lipid nanoparticles with neutral zeta potential
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