Select RnD Updates from Global Journals

RSS New England Journal of Medicine

  • Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial April 15, 2021
    Nonanastomotic biliary strictures are a major complication after liver transplantation, resulting in cholestasis and cholangitis and, frequently, in the use of biliary interventions or even retransplantation (i.e. transplantation of a new liver graft and removal of the first graft). The incidence…
  • Warming Up to Cold Perfusion April 15, 2021
    Each year, thousands of people in the United States die while awaiting lifesaving liver transplantation because there is an insufficient supply of donor organs. This crisis has prompted increased interest in expanding the organ supply through the promotion of both deceased and live liver donation…
  • Sutimlimab in Cold Agglutinin Disease April 8, 2021
    Patients with cold agglutinin disease, a rare autoimmune hemolytic anemia, often have chronic anemia, profound fatigue, and acute hemolytic crisis. These patients may also have agglutination-mediated acrocyanosis and a higher risk of thromboembolism and early death. Cold agglutinin disease is…

RSS New England Journal of Medicine

  • Remote Patient Monitoring — Overdue or Overused? April 15, 2021
    The Covid-19 pandemic has challenged clinicians to find innovative ways to provide essential services while minimizing risks for themselves and their patients. These approaches increasingly leverage remote patient monitoring (RPM), using technology to support treatment for chronic conditions. As…
  • Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination April 9, 2021
    Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the most important countermeasure to fight the coronavirus 2019 (Covid-19) pandemic. From December 2020 through March 2021, the European Medicines Agency approved four vaccines on the basis of randomized, blinded,…
  • Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination April 9, 2021
    The European Medicines Agency has approved five vaccines against coronavirus disease 2019 (Covid-19), and more than 600 million doses have been administered globally. In Norway, older adults living in institutional settings and health care professionals who are in close contact with patients with…

RSS JAMA

RSS New England Journal of Medicine

RSS JAMA

RSS New England Journal of Medicine

  • Remote Patient Monitoring — Overdue or Overused? April 15, 2021
    The Covid-19 pandemic has challenged clinicians to find innovative ways to provide essential services while minimizing risks for themselves and their patients. These approaches increasingly leverage remote patient monitoring (RPM), using technology to support treatment for chronic conditions. As…
  • Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality April 8, 2021
    Concern over the health effects of poor-quality carbohydrate foods and beverages has increased the popularity of so-called low-carbohydrate diets. Poor-quality carbohydrate foods include those that contain a low amount of fiber, a higher percentage of refined grains than whole grains, and a high…
  • Stalking the Diagnosis April 1, 2021
    Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 22-year-old man…

RSS New England Journal of Medicine

  • Audio Interview: Vaccine Successes and Vaccine Adverse Events April 15, 2021
    The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
  • No More Surprises — New Legislation on Out-of-Network Billing April 15, 2021
    The passage of the No Surprises Act — which banned "surprise billing" in many scenarios — on December 27, 2020, was an unexpected step forward during an otherwise dysfunctional year of U.S. policymaking. As many as one in five patients visiting an emergency department or undergoing elective surgery…
  • Race, Policing, and History — Remembering the Freedom House Ambulance Service April 15, 2021
    Americans protesting violent policing of Black communities are calling for law-enforcement budgets to be reallocated to community health services. Although such proposals are sometimes dismissed as naive or unrealistic, history provides an example of a transfer of power and resources from police to…

RSS New England Journal of Medicine

  • Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial April 15, 2021
    Nonanastomotic biliary strictures are a major complication after liver transplantation, resulting in cholestasis and cholangitis and, frequently, in the use of biliary interventions or even retransplantation (i.e. transplantation of a new liver graft and removal of the first graft). The incidence…
  • Warming Up to Cold Perfusion April 15, 2021
    Each year, thousands of people in the United States die while awaiting lifesaving liver transplantation because there is an insufficient supply of donor organs. This crisis has prompted increased interest in expanding the organ supply through the promotion of both deceased and live liver donation…
  • Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality April 8, 2021
    Concern over the health effects of poor-quality carbohydrate foods and beverages has increased the popularity of so-called low-carbohydrate diets. Poor-quality carbohydrate foods include those that contain a low amount of fiber, a higher percentage of refined grains than whole grains, and a high…

RSS New England Journal of Medicine

  • Palmoplantar Papules April 15, 2021
    Figure 1.
  • Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine April 15, 2021
    To the Editor: The mRNA-1273 vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicited high neutralizing-antibody titers in phase 1 trial participants and has been shown to be highly efficacious in preventing symptomatic Covid-19 disease and severe disease. The…
  • Neutralizing Activity of BNT162b2-Elicited Serum April 15, 2021
    To the Editor: BNT162b2 is a nucleoside-modified RNA vaccine expressing the full-length prefusion spike glycoprotein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In a randomized, placebo-controlled clinical trial involving approximately 44,000 participants, immunization…

RSS New England Journal of Medicine

  • Case 10-2021: A 70-Year-Old Man with Depressed Mood, Unsteady Gait, and Urinary Incontinence April 8, 2021
    Presentation of Case. Dr. James W. Luccarelli (Psychiatry): A 70-year-old man with bipolar disorder was evaluated at this hospital because of depressed mood, suicidal ideation, and gait disturbance. The patient had a long history of depressive episodes, with two previous hospitalizations for…
  • Learning How to Die — Lessons from the Irish Wake February 11, 2021
    I didn’t want to believe it. I vividly remember when he blindfolded and "kidnapped" my siblings and me, surprising us with an all-day trip to Camp Snoopy, our favorite theme park. And I probably wouldn’t have believed it, if it weren’t for the unfamiliar, sober look on my dad’s face when he told me…
  • Circadian Mechanisms in Medicine February 11, 2021
    In addition to the sleep–wake cycle and cognitive functions such as learning and memory, intrinsic clocks determine nearly all circadian cycles in physiology, such as daily variation in blood pressure, heart rate, hormone levels, respiratory and exercise capacity, and coagulation. Many pathologic…

RSS New England Journal of Medicine

  • Palmoplantar Papules April 15, 2021
    Figure 1.
  • Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination April 9, 2021
    Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the most important countermeasure to fight the coronavirus 2019 (Covid-19) pandemic. From December 2020 through March 2021, the European Medicines Agency approved four vaccines on the basis of randomized, blinded,…
  • Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination April 9, 2021
    The European Medicines Agency has approved five vaccines against coronavirus disease 2019 (Covid-19), and more than 600 million doses have been administered globally. In Norway, older adults living in institutional settings and health care professionals who are in close contact with patients with…

RSS New England Journal of Medicine

  • No More Surprises — New Legislation on Out-of-Network Billing April 15, 2021
    The passage of the No Surprises Act — which banned "surprise billing" in many scenarios — on December 27, 2020, was an unexpected step forward during an otherwise dysfunctional year of U.S. policymaking. As many as one in five patients visiting an emergency department or undergoing elective surgery…
  • Race, Policing, and History — Remembering the Freedom House Ambulance Service April 15, 2021
    Americans protesting violent policing of Black communities are calling for law-enforcement budgets to be reallocated to community health services. Although such proposals are sometimes dismissed as naive or unrealistic, history provides an example of a transfer of power and resources from police to…
  • No Cure without Care — Soothing Science Skepticism April 15, 2021
    A few weeks ago, I cared for a patient, Mr. C. who had a history of bleeding from antiplatelet therapy but remained at high risk for thrombosis. At the time we met, he had just been extubated and, still a bit loopy from the sedation, couldn’t give many details about the previous bleeds or…

RSS New England Journal of Medicine

  • Audio Interview: Vaccine Successes and Vaccine Adverse Events April 15, 2021
    The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
  • Neutralizing Activity of BNT162b2-Elicited Serum April 15, 2021
    To the Editor: BNT162b2 is a nucleoside-modified RNA vaccine expressing the full-length prefusion spike glycoprotein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In a randomized, placebo-controlled clinical trial involving approximately 44,000 participants, immunization…
  • Case 11-2021: A 39-Year-Old Woman with Fever, Flank Pain, and Inguinal Lymphadenopathy April 15, 2021
    Presentation of Case. Dr. P. Connor Johnson (Medicine): A 39-year-old woman presented to this hospital with fever, flank pain, and tender inguinal lymphadenopathy. The patient had been in her usual state of health until approximately 4 weeks before admission, when she noted tender bilateral…

RSS JAMA

RSS New England Journal of Medicine

  • Insights into Glomerular Filtration and Albuminuria April 15, 2021
    Chronic kidney diseases affect more than 10% of the world’s population, and most cases arise from disorders of the kidney’s filtration barrier, which is located within a million microvascular units called glomeruli. Although it has been known for many decades that, in the kidney, glomeruli are the…
  • A Step Ahead in Metastatic Renal Cell Carcinoma April 8, 2021
    Motzer et al. report in the Journal the efficacy and safety of pembrolizumab, an anti–programmed cell death 1 (PD-1) monoclonal antibody, used in combination with lenvatinib, an antiangiogenic drug (a vascular endothelial growth factor receptor [VEGFR] tyrosine kinase inhibitor), as compared with…
  • Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma April 8, 2021
    First-line treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitors has been shown to provide benefits for patients with advanced renal cell carcinoma, but most patients have disease relapse as resistance develops. Treatment with immune-checkpoint inhibitors, either as…

RSS New England Journal of Medicine

  • Back to the Future — The Therapeutic Potential of Psychedelic Drugs April 15, 2021
    In The Doors of Perception, Aldous Huxley described his trial of mescaline as "the most extraordinary and significant experience available to human beings this side of the Beatific Vision." His exegesis was preceded by the synthesis of the hallucinogen lysergic acid diethylamide (LSD) by Sandoz…
  • Trial of Psilocybin versus Escitalopram for Depression April 15, 2021
    Major depressive disorder affects approximately 10% of the general population in the United Kingdom, impairs patients’ lives, and is costly to society. Selective serotonin-reuptake inhibitors are first-line treatments for major depressive disorder; however, these drugs take several weeks to work…
  • Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas April 10, 2021
    Malignant high-grade glioma accounts for 8 to 10% of pediatric brain tumors and is regularly fatal, with a rapid course. Survival rates have not improved in 30 years; the 3-year event-free survival among patients with newly diagnosed tumors who are treated with standard radiation and chemotherapy…

RSS JAMA

  • Electronic Cigarette Use and Cigarette-Smoking Cessation Attempts Among Stroke Survivors in the US April 12, 2021
    This cross-sectional study estimates the prevalence of electronic cigarette use among actively smoking stroke survivors in the US and evaluates its association with at least 1 cigarette-smoking cessation attempt in the past year.
  • The Impact of Stuttering—Hiding in Plain Sight April 12, 2021
    This Viewpoint discusses the mechanics and misconceptions of stuttering and the importance of a multidisciplinary approach in the study and treatment of people who stutter.
  • Error in Title and Text April 12, 2021
    The Images in Neurology article “Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy With the Detection of Anti-GM3 and Anti-GM4 IgG Antibodies, Masquerading as Brown-Sequared Syndrome,” published in the January 2021 issue, had an error in the spelling of the eponym “Sequard” (as “Sequared”) in the title and throughout the text. The error has been corrected online.

RSS New England Journal of Medicine

RSS New England Journal of Medicine

  • Palmoplantar Papules April 15, 2021
    Figure 1.
  • Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination April 9, 2021
    Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the most important countermeasure to fight the coronavirus 2019 (Covid-19) pandemic. From December 2020 through March 2021, the European Medicines Agency approved four vaccines on the basis of randomized, blinded,…
  • Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination April 9, 2021
    The European Medicines Agency has approved five vaccines against coronavirus disease 2019 (Covid-19), and more than 600 million doses have been administered globally. In Norway, older adults living in institutional settings and health care professionals who are in close contact with patients with…

RSS JAMA

RSS JAMA

RSS JAMA

RSS JAMA

RSS New England Journal of Medicine

RSS JAMA

RSS New England Journal of Medicine

RSS New England Journal of Medicine

  • Trial of Psilocybin versus Escitalopram for Depression April 15, 2021
    Major depressive disorder affects approximately 10% of the general population in the United Kingdom, impairs patients’ lives, and is costly to society. Selective serotonin-reuptake inhibitors are first-line treatments for major depressive disorder; however, these drugs take several weeks to work…
  • Back to the Future — The Therapeutic Potential of Psychedelic Drugs April 15, 2021
    In The Doors of Perception, Aldous Huxley described his trial of mescaline as "the most extraordinary and significant experience available to human beings this side of the Beatific Vision." His exegesis was preceded by the synthesis of the hallucinogen lysergic acid diethylamide (LSD) by Sandoz…
  • Case 10-2021: A 70-Year-Old Man with Depressed Mood, Unsteady Gait, and Urinary Incontinence April 8, 2021
    Presentation of Case. Dr. James W. Luccarelli (Psychiatry): A 70-year-old man with bipolar disorder was evaluated at this hospital because of depressed mood, suicidal ideation, and gait disturbance. The patient had a long history of depressive episodes, with two previous hospitalizations for…

RSS JAMA

  • Moving Beyond μ Medications April 14, 2021
    This Viewpoint discusses the potential use of non-μ treatments of opioid use disorder and provides an overview of considerations for the field as it moves to develop such agents.
  • Suicide Risk Among US Nurses and Physicians April 14, 2021
    This cohort study estimates the national incidence of suicide among nurses and examines characteristics of nurse suicides compared with physicians and the general population.
  • Rate of Suicide Among Women Nurses Compared With in the General Population Before the COVID-19 Global Pandemic April 14, 2021
    In this issue of JAMA Psychiatry, Davis et al have identified a population at high risk for suicide that warrants immediate attention. In a large retrospective cohort study of 159 372 suicides from 2007 to 2018 in the United States, sex-specific suicide incidence rates among nurses, physicians, and the general population were estimated using data from […]

RSS New England Journal of Medicine

  • Audio Interview: Vaccine Successes and Vaccine Adverse Events April 15, 2021
    The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
  • Remote Patient Monitoring — Overdue or Overused? April 15, 2021
    The Covid-19 pandemic has challenged clinicians to find innovative ways to provide essential services while minimizing risks for themselves and their patients. These approaches increasingly leverage remote patient monitoring (RPM), using technology to support treatment for chronic conditions. As…
  • Warming Up to Cold Perfusion April 15, 2021
    Each year, thousands of people in the United States die while awaiting lifesaving liver transplantation because there is an insufficient supply of donor organs. This crisis has prompted increased interest in expanding the organ supply through the promotion of both deceased and live liver donation…

RSS New England Journal of Medicine

  • Sunken Nose April 8, 2021
    Figure 1.
  • Trial of Upadacitinib and Adalimumab for Psoriatic Arthritis April 1, 2021
    Upadacitinib is an oral, reversible Janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis. Adalimumab is a tumor necrosis factor α inhibitor used to treat rheumatoid arthritis and psoriatic arthritis. In one trial involving patients with rheumatoid arthritis, upadacitinib…
  • Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis March 25, 2021
    Atopic dermatitis is a common, chronic inflammatory skin disease associated with itch, pain, sleep disturbance, anxiety, depression, and increased health care utilization. When topical therapies are insufficient, treatment with systemic agents, including dupilumab and immunosuppressants, has been…

RSS New England Journal of Medicine

  • Warming Up to Cold Perfusion April 15, 2021
    Each year, thousands of people in the United States die while awaiting lifesaving liver transplantation because there is an insufficient supply of donor organs. This crisis has prompted increased interest in expanding the organ supply through the promotion of both deceased and live liver donation…
  • Closed Gastroschisis April 15, 2021
    Figure 1.
  • Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial April 15, 2021
    Nonanastomotic biliary strictures are a major complication after liver transplantation, resulting in cholestasis and cholangitis and, frequently, in the use of biliary interventions or even retransplantation (i.e. transplantation of a new liver graft and removal of the first graft). The incidence…

RSS JAMA