Select RnD Updates from Global Journals

RSS New England Journal of Medicine

  • Case 22-2021: A 64-Year-Old Woman with Cognitive Impairment, Headache, and Memory Loss July 22, 2021
    Presentation of Case. Dr. Giovanna S. Manzano (Neurology): A 64-year-old woman was admitted to this hospital with cognitive impairment, headache, and memory loss. The patient had been well until 6 weeks before admission, when respiratory symptoms developed. Testing of a nasopharyngeal swab for…
  • Transglutaminase 2 Inhibition for Prevention of Mucosal Damage in Celiac Disease July 1, 2021
    Celiac disease is a T-cell–mediated enteropathy induced by dietary gluten that shares many features with organ-specific autoimmune disorders. Celiac disease requires the presence of autoantibodies directed against the endogenous enzyme tissue transglutaminase 2 and occurs selectively in persons in…
  • Immunotherapy for MIS-C — IVIG, Glucocorticoids, and Biologics July 1, 2021
    Since the sudden emergence of multisystem inflammatory disease in children (MIS-C) in April 2020 as a novel and severe presentation of coronavirus disease 2019 (Covid-19), nearly 4000 cases of MIS-C and 35 deaths have been reported in the United States and many more internationally. A steep…

RSS New England Journal of Medicine

  • PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia July 22, 2021
    To the Editor: In a recent study, Greinacher et al. reported thrombotic complications, mostly cerebral vein thrombosis, associated with thrombocytopenia in 11 patients after they had been vaccinated with ChAdOx1 nCoV-19 (AstraZeneca). Although none of these patients had received heparin, the…
  • PCI for Nonculprit Lesions in Patients with STEMI — No Role for FFR July 22, 2021
    Approximately 50% of patients with acute ST-segment elevation myocardial infarction (STEMI) have multivessel disease. For such patients, a major clinical question has been whether percutaneous coronary intervention (PCI) should be performed only on the coronary occlusion causing the infarct (the…
  • Multivessel PCI Guided by FFR or Angiography for Myocardial Infarction July 22, 2021
    In patients with chronic coronary syndrome or acute coronary syndrome without ST-segment elevation, the use of fractional flow reserve (FFR) measurement during percutaneous coronary intervention (PCI) to assess the functional severity of coronary lesions results in a lower risk of major…

RSS JAMA

RSS JAMA

RSS New England Journal of Medicine

  • One Hundred Years of Insulin for Some July 22, 2021
    There is not one story of insulin; there are many. As a young child, Mr. J. lost his mother to what was presumed to be type 1 diabetes. He recalled taking whatever kinds of insulin he could get for his own type 1 diabetes growing up, thanks to the generosity of his neighbors and extended […]
  • PTH Infusion for Seizures in Autosomal Dominant Hypocalcemia Type 1 July 8, 2021
    To the Editor: Autosomal dominant hypocalcemia type 1 (ADH1) is caused by gain-of-function mutations in the gene encoding the calcium-sensing receptor (CASR), a condition that results in hypocalcemia and seizures, hypomagnesemia, hyperphosphatemia, reduced parathyroid hormone (PTH) levels, and…
  • Breaking New Ground with Incretin Therapy in Diabetes June 25, 2021
    The number of persons with diabetes is projected to grow from 463 million to 700 million worldwide between 2019 and 2045, with the greatest effect occurring in low- and middle-income countries. Given the growing number of cases of diabetes (90% of which are type 2), an increased incidence of…

RSS New England Journal of Medicine

RSS New England Journal of Medicine

  • Infantile Hepatic Hemangiomas July 15, 2021
    Figure 1.
  • Hepatocellular Carcinoma — Origins and Outcomes July 15, 2021
    Hepatocellular carcinoma is a cancer associated with underlying inflammation. Although infection with hepatitis B or C virus continues to account for the majority of cases of hepatocellular carcinoma, the population-attributable fraction due to nonalcoholic fatty liver disease (NAFLD) is rising…
  • Case 21-2021: A 33-Year-Old Pregnant Woman with Fever, Abdominal Pain, and Headache July 15, 2021
    Presentation of Case. Dr. Kathy M. Tran: A 33-year-old pregnant woman with ulcerative colitis was admitted to this hospital during the summer at 10 weeks of gestation because of fever, nausea, vomiting, abdominal pain and tenderness, and headache. The patient had been in her usual state of health…

RSS New England Journal of Medicine

  • Freedom of Speech July 15, 2021
    Of the many functions delegated to the human nervous system, perhaps none is more essentially human than the ability to express one’s thoughts. For persons with severe speech and motor impairments, restoration of the ability to communicate even simple needs is an important goal. Cognitively intact…
  • Hepatocellular Carcinoma — Origins and Outcomes July 15, 2021
    Hepatocellular carcinoma is a cancer associated with underlying inflammation. Although infection with hepatitis B or C virus continues to account for the majority of cases of hepatocellular carcinoma, the population-attributable fraction due to nonalcoholic fatty liver disease (NAFLD) is rising…
  • Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria July 15, 2021
    Anarthria is the loss of the ability to articulate speech. It can result from a variety of conditions, including stroke and amyotrophic lateral sclerosis. Patients with anarthria may have intact language skills and cognition, and some are able to produce limited oral movements and undifferentiated…

RSS New England Journal of Medicine

  • Trial of Pimavanserin in Dementia-Related Psychosis July 22, 2021
    The most common causes of dementia — Alzheimer’s disease, dementia with Lewy bodies, Parkinson’s disease dementia, vascular dementia, and frontotemporal dementia — may be associated with hallucinations and delusions. This syndrome of dementia-related psychosis causes behavioral disturbances,…
  • Pimavanserin in Dementia-Related Psychosis July 22, 2021
    Dementia occurs in a range of progressive neurodegenerative brain disorders, including Alzheimer’s disease, dementia with Lewy bodies, Parkinson’s disease dementia, vascular dementia, and frontotemporal dementia, each classified according to their respective neuropathological characteristics.…
  • Exercise for Frail, Elderly Patients with Acute Heart Failure — A Strong Step Forward July 15, 2021
    Exercise rehabilitation has a long history in the management of chronic heart failure, with the first randomized trial of exercise training dating back to 1990 — and by the late 1990s, it had become an integral part of therapy. There is solid evidence from multiple trials and meta-analyses that…

RSS New England Journal of Medicine

  • Case 22-2021: A 64-Year-Old Woman with Cognitive Impairment, Headache, and Memory Loss July 22, 2021
    Presentation of Case. Dr. Giovanna S. Manzano (Neurology): A 64-year-old woman was admitted to this hospital with cognitive impairment, headache, and memory loss. The patient had been well until 6 weeks before admission, when respiratory symptoms developed. Testing of a nasopharyngeal swab for…
  • PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia July 22, 2021
    To the Editor: In a recent study, Greinacher et al. reported thrombotic complications, mostly cerebral vein thrombosis, associated with thrombocytopenia in 11 patients after they had been vaccinated with ChAdOx1 nCoV-19 (AstraZeneca). Although none of these patients had received heparin, the…
  • Abelacimab for Prevention of Venous Thromboembolism July 19, 2021
    Patients undergoing total knee arthroplasty are at high risk for postoperative venous thromboembolism. Enoxaparin, an inhibitor of factor Xa and thrombin, is often administered postoperatively to reduce this risk. Although reasonably effective, enoxaparin can be associated with bleeding. A search…

RSS New England Journal of Medicine

  • Racial Inequality in Prescription Opioid Receipt — Role of Individual Health Systems July 22, 2021
    The receipt of prescription opioid analgesics in the United States differs according to skin color despite a lack of evidence of racial differences in pain perception or in preferences for pain management. National, regional, and single-institution studies involving adults have consistently shown…
  • Covid-19 Vaccine Acceptance in California State Prisons July 22, 2021
    To the Editor: Prisons and jails are high-risk settings for Covid-19, with case and mortality rates far exceeding those in the general community. More incarcerated people have died from Covid-19 in U.S. correctional facilities in the past year than died by capital punishment in the past 70 years.…
  • Medical–Financial Partnerships — Beyond Traditional Boundaries July 22, 2021
    Poverty is associated with lifelong poor health and has been largely unaddressed in medical practice. More broadly, financial instability, which encompasses circumstances such as a lack of emergency savings and a dependence on gig work, affects half of Americans and is also associated with poor…

RSS New England Journal of Medicine

  • Covid-19 Vaccine Acceptance in California State Prisons July 22, 2021
    To the Editor: Prisons and jails are high-risk settings for Covid-19, with case and mortality rates far exceeding those in the general community. More incarcerated people have died from Covid-19 in U.S. correctional facilities in the past year than died by capital punishment in the past 70 years.…
  • Case 22-2021: A 64-Year-Old Woman with Cognitive Impairment, Headache, and Memory Loss July 22, 2021
    Presentation of Case. Dr. Giovanna S. Manzano (Neurology): A 64-year-old woman was admitted to this hospital with cognitive impairment, headache, and memory loss. The patient had been well until 6 weeks before admission, when respiratory symptoms developed. Testing of a nasopharyngeal swab for…
  • Audio Interview: The Impact of Covid-19 on Trainees and Junior Faculty July 22, 2021
    The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…

RSS JAMA

RSS New England Journal of Medicine

  • Hematuria in Adults July 8, 2021
    Visible (macroscopic) hematuria, documented since ancient times, is striking, particularly when there is no prior event, such as trauma, dysuria due to cystitis, or flank pain with passage of a kidney stone, to provide a clear explanation. In contrast, nonvisible (microscopic) hematuria, or…
  • PTH Infusion for Seizures in Autosomal Dominant Hypocalcemia Type 1 July 8, 2021
    To the Editor: Autosomal dominant hypocalcemia type 1 (ADH1) is caused by gain-of-function mutations in the gene encoding the calcium-sensing receptor (CASR), a condition that results in hypocalcemia and seizures, hypomagnesemia, hyperphosphatemia, reduced parathyroid hormone (PTH) levels, and…
  • Breaking New Ground with Incretin Therapy in Diabetes June 25, 2021
    The number of persons with diabetes is projected to grow from 463 million to 700 million worldwide between 2019 and 2045, with the greatest effect occurring in low- and middle-income countries. Given the growing number of cases of diabetes (90% of which are type 2), an increased incidence of…

RSS New England Journal of Medicine

  • Racial Inequality in Prescription Opioid Receipt — Role of Individual Health Systems July 22, 2021
    The receipt of prescription opioid analgesics in the United States differs according to skin color despite a lack of evidence of racial differences in pain perception or in preferences for pain management. National, regional, and single-institution studies involving adults have consistently shown…
  • Trial of Pimavanserin in Dementia-Related Psychosis July 22, 2021
    The most common causes of dementia — Alzheimer’s disease, dementia with Lewy bodies, Parkinson’s disease dementia, vascular dementia, and frontotemporal dementia — may be associated with hallucinations and delusions. This syndrome of dementia-related psychosis causes behavioral disturbances,…
  • Pimavanserin in Dementia-Related Psychosis July 22, 2021
    Dementia occurs in a range of progressive neurodegenerative brain disorders, including Alzheimer’s disease, dementia with Lewy bodies, Parkinson’s disease dementia, vascular dementia, and frontotemporal dementia, each classified according to their respective neuropathological characteristics.…

RSS JAMA

RSS New England Journal of Medicine

  • Case 21-2021: A 33-Year-Old Pregnant Woman with Fever, Abdominal Pain, and Headache July 15, 2021
    Presentation of Case. Dr. Kathy M. Tran: A 33-year-old pregnant woman with ulcerative colitis was admitted to this hospital during the summer at 10 weeks of gestation because of fever, nausea, vomiting, abdominal pain and tenderness, and headache. The patient had been in her usual state of health…
  • Medical Home July 15, 2021
  • Fetal Tracheal Occlusion for Congenital Diaphragmatic Hernia July 8, 2021
    The modern era of fetal surgical interventions began in the 1980s, when improved ultrasonographic imaging enabled prenatal detection of life-limiting birth defects. However, the rarity of many severe fetal anomalies, maternal complications associated with open fetal interventions, and the…

RSS New England Journal of Medicine

  • Case 22-2021: A 64-Year-Old Woman with Cognitive Impairment, Headache, and Memory Loss July 22, 2021
    Presentation of Case. Dr. Giovanna S. Manzano (Neurology): A 64-year-old woman was admitted to this hospital with cognitive impairment, headache, and memory loss. The patient had been well until 6 weeks before admission, when respiratory symptoms developed. Testing of a nasopharyngeal swab for…
  • PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia July 22, 2021
    To the Editor: In a recent study, Greinacher et al. reported thrombotic complications, mostly cerebral vein thrombosis, associated with thrombocytopenia in 11 patients after they had been vaccinated with ChAdOx1 nCoV-19 (AstraZeneca). Although none of these patients had received heparin, the…
  • Abelacimab for Prevention of Venous Thromboembolism July 19, 2021
    Patients undergoing total knee arthroplasty are at high risk for postoperative venous thromboembolism. Enoxaparin, an inhibitor of factor Xa and thrombin, is often administered postoperatively to reduce this risk. Although reasonably effective, enoxaparin can be associated with bleeding. A search…

RSS JAMA

RSS JAMA

RSS JAMA

RSS JAMA

RSS New England Journal of Medicine

  • Medical–Financial Partnerships — Beyond Traditional Boundaries July 22, 2021
    Poverty is associated with lifelong poor health and has been largely unaddressed in medical practice. More broadly, financial instability, which encompasses circumstances such as a lack of emergency savings and a dependence on gig work, affects half of Americans and is also associated with poor…
  • One Hundred Years of Insulin for Some July 22, 2021
    There is not one story of insulin; there are many. As a young child, Mr. J. lost his mother to what was presumed to be type 1 diabetes. He recalled taking whatever kinds of insulin he could get for his own type 1 diabetes growing up, thanks to the generosity of his neighbors and extended […]
  • Infantile Hepatic Hemangiomas July 15, 2021
    Figure 1.

RSS JAMA

RSS New England Journal of Medicine

  • Racial Inequality in Prescription Opioid Receipt — Role of Individual Health Systems July 22, 2021
    The receipt of prescription opioid analgesics in the United States differs according to skin color despite a lack of evidence of racial differences in pain perception or in preferences for pain management. National, regional, and single-institution studies involving adults have consistently shown…
  • Trial of Pimavanserin in Dementia-Related Psychosis July 22, 2021
    The most common causes of dementia — Alzheimer’s disease, dementia with Lewy bodies, Parkinson’s disease dementia, vascular dementia, and frontotemporal dementia — may be associated with hallucinations and delusions. This syndrome of dementia-related psychosis causes behavioral disturbances,…
  • Pimavanserin in Dementia-Related Psychosis July 22, 2021
    Dementia occurs in a range of progressive neurodegenerative brain disorders, including Alzheimer’s disease, dementia with Lewy bodies, Parkinson’s disease dementia, vascular dementia, and frontotemporal dementia, each classified according to their respective neuropathological characteristics.…

RSS New England Journal of Medicine

  • Pimavanserin in Dementia-Related Psychosis July 22, 2021
    Dementia occurs in a range of progressive neurodegenerative brain disorders, including Alzheimer’s disease, dementia with Lewy bodies, Parkinson’s disease dementia, vascular dementia, and frontotemporal dementia, each classified according to their respective neuropathological characteristics.…
  • Substance Use among Men Who Have Sex with Men July 22, 2021
    In recent years, the social acceptance of and legal protections extended to persons in sexual minority groups have been increasing in many countries, including the United States. Despite this progress, stigma, discrimination, and structural barriers to services persist, causing health disparities…
  • Trial of Pimavanserin in Dementia-Related Psychosis July 22, 2021
    The most common causes of dementia — Alzheimer’s disease, dementia with Lewy bodies, Parkinson’s disease dementia, vascular dementia, and frontotemporal dementia — may be associated with hallucinations and delusions. This syndrome of dementia-related psychosis causes behavioral disturbances,…

RSS JAMA

RSS New England Journal of Medicine

RSS New England Journal of Medicine

RSS JAMA

  • Comments on Computed Tomography for Evaluating Appendicitis—Reply July 21, 2021
    In Reply We thank Hu et al, McCollough et al, and Schaps et al for their comments on our article. We hope that our study findings can contribute to better use of computed tomography (CT), rather than inciting unnecessary fear of CT radiation. In that regard, we appreciate them as they led the constructive discussion […]
  • Comments on Computed Tomography for Evaluating Appendicitis July 21, 2021
    To the Editor We read with interest the article by Lee et al who suggest an association between computed tomography (CT) exposure and risk of hematologic malignant neoplasms after CT scan for evaluation of acute appendicitis. Among their findings, the authors report that the greatest relative risk of developing a hematologic malignant neoplasm following CT […]
  • Comments on Computed Tomography for Evaluating Appendicitis July 21, 2021
    To the Editor We are writing as members of the American Association of Physicists in Medicine to reflect on the article by Lee et al regarding the risk of malignant neoplasm subsequent to computed tomography (CT) in patients who underwent appendectomy. We commend the authors for acknowledging the controversy surrounding this topic and citing references […]