Select RnD Updates from Global Journals

RSS New England Journal of Medicine

  • Vancomycin Infusion Reaction — Moving beyond "Red Man Syndrome" April 8, 2021
    In 1959, an article entitled "An Anaphylactoid Reaction to Vancomycin" hypothesized that vancomycin-induced histamine release from mast cells had clinical manifestations similar to those of anaphylaxis but less severe. The author named this reaction "Red Man Syndrome," reflecting the diffuse…
  • Sutimlimab in Cold Agglutinin Disease April 8, 2021
    Patients with cold agglutinin disease, a rare autoimmune hemolytic anemia, often have chronic anemia, profound fatigue, and acute hemolytic crisis. These patients may also have agglutination-mediated acrocyanosis and a higher risk of thromboembolism and early death. Cold agglutinin disease is…
  • Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria March 18, 2021
    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, clonal, nonmalignant hematologic disease characterized by complement-mediated hemolysis (with or without hemoglobinuria), fatigue, increased susceptibility to thrombosis, and some degree of bone marrow dysfunction. PNH results from the…

RSS New England Journal of Medicine

  • Remote Patient Monitoring — Overdue or Overused? April 10, 2021
    The Covid-19 pandemic has challenged clinicians to find innovative ways to provide essential services while minimizing risks for themselves and their patients. These approaches increasingly leverage remote patient monitoring (RPM), using technology to support treatment for chronic conditions. As…
  • Base Editing in Progeria April 8, 2021
    "How much longer?" is a question all too familiar to parents. This is also a question that scientists ask themselves when trying to find a truly effective treatment for patients with the Hutchinson–Gilford progeria syndrome (HGPS) and other genetic diseases. Koblan et al. recently described a…
  • Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality April 8, 2021
    Concern over the health effects of poor-quality carbohydrate foods and beverages has increased the popularity of so-called low-carbohydrate diets. Poor-quality carbohydrate foods include those that contain a low amount of fiber, a higher percentage of refined grains than whole grains, and a high…

RSS JAMA

RSS New England Journal of Medicine

RSS JAMA

RSS New England Journal of Medicine

  • Remote Patient Monitoring — Overdue or Overused? April 10, 2021
    The Covid-19 pandemic has challenged clinicians to find innovative ways to provide essential services while minimizing risks for themselves and their patients. These approaches increasingly leverage remote patient monitoring (RPM), using technology to support treatment for chronic conditions. As…
  • Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality April 8, 2021
    Concern over the health effects of poor-quality carbohydrate foods and beverages has increased the popularity of so-called low-carbohydrate diets. Poor-quality carbohydrate foods include those that contain a low amount of fiber, a higher percentage of refined grains than whole grains, and a high…
  • Stalking the Diagnosis April 1, 2021
    Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 22-year-old man…

RSS New England Journal of Medicine

  • Race, Policing, and History — Remembering the Freedom House Ambulance Service April 10, 2021
    Americans protesting violent policing of Black communities are calling for law-enforcement budgets to be reallocated to community health services. Although such proposals are sometimes dismissed as naive or unrealistic, history provides an example of a transfer of power and resources from police to…
  • Audio Interview: Antibody Responses to Natural Infection and Vaccination April 8, 2021
    The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
  • Audio Interview: Delivering Covid-19 Vaccines to Minority Communities April 1, 2021
    The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…

RSS New England Journal of Medicine

  • Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality April 8, 2021
    Concern over the health effects of poor-quality carbohydrate foods and beverages has increased the popularity of so-called low-carbohydrate diets. Poor-quality carbohydrate foods include those that contain a low amount of fiber, a higher percentage of refined grains than whole grains, and a high…
  • A Microbiota-Directed Food Intervention for Undernourished Children April 7, 2021
    Childhood undernutrition is a global health challenge that produces impaired ponderal and linear growth (wasting and stunting), immune and metabolic dysfunction, altered development of the central nervous system (CNS), and other abnormalities. Acute malnutrition in children is classified by the…
  • Adjuvant Nivolumab in Esophageal Cancer — A New Standard of Care April 1, 2021
    Esophageal cancer is a leading cause of cancer-related illness and death throughout the world. Because there is no effective screening or early detection, most patients present with locally advanced or overt metastatic disease. Esophageal squamous-cell carcinoma is the most common histologic type…

RSS New England Journal of Medicine

  • Vestibular Schwannomas April 8, 2021
    Vestibular schwannomas account for 8% of all intracranial tumors and are the most common neoplasm of the cerebellopontine angle in adults. These tumors derive from myelinating Schwann cells of the vestibular division of the vestibulocochlear (eighth cranial) nerve. The term "vestibular schwannoma"…
  • Base Editing in Progeria April 8, 2021
    "How much longer?" is a question all too familiar to parents. This is also a question that scientists ask themselves when trying to find a truly effective treatment for patients with the Hutchinson–Gilford progeria syndrome (HGPS) and other genetic diseases. Koblan et al. recently described a…
  • Microbial Nourishment for Undernutrition April 7, 2021
    Hippocrates wrote "let food be thy medicine." Although access to nourishing food seems to be an obvious solution to the global health crisis of childhood undernutrition, the solution is not simple from a social or metabolic perspective, or even from the perspective of a microbiologist. To…

RSS New England Journal of Medicine

  • Case 10-2021: A 70-Year-Old Man with Depressed Mood, Unsteady Gait, and Urinary Incontinence April 8, 2021
    Presentation of Case. Dr. James W. Luccarelli (Psychiatry): A 70-year-old man with bipolar disorder was evaluated at this hospital because of depressed mood, suicidal ideation, and gait disturbance. The patient had a long history of depressive episodes, with two previous hospitalizations for…
  • Learning How to Die — Lessons from the Irish Wake February 11, 2021
    I didn’t want to believe it. I vividly remember when he blindfolded and "kidnapped" my siblings and me, surprising us with an all-day trip to Camp Snoopy, our favorite theme park. And I probably wouldn’t have believed it, if it weren’t for the unfamiliar, sober look on my dad’s face when he told me…
  • Circadian Mechanisms in Medicine February 11, 2021
    In addition to the sleep–wake cycle and cognitive functions such as learning and memory, intrinsic clocks determine nearly all circadian cycles in physiology, such as daily variation in blood pressure, heart rate, hormone levels, respiratory and exercise capacity, and coagulation. Many pathologic…

RSS New England Journal of Medicine

  • A Step Ahead in Metastatic Renal Cell Carcinoma April 8, 2021
    Motzer et al. report in the Journal the efficacy and safety of pembrolizumab, an anti–programmed cell death 1 (PD-1) monoclonal antibody, used in combination with lenvatinib, an antiangiogenic drug (a vascular endothelial growth factor receptor [VEGFR] tyrosine kinase inhibitor), as compared with…
  • Sutimlimab in Cold Agglutinin Disease April 8, 2021
    Patients with cold agglutinin disease, a rare autoimmune hemolytic anemia, often have chronic anemia, profound fatigue, and acute hemolytic crisis. These patients may also have agglutination-mediated acrocyanosis and a higher risk of thromboembolism and early death. Cold agglutinin disease is…
  • Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma April 8, 2021
    First-line treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitors has been shown to provide benefits for patients with advanced renal cell carcinoma, but most patients have disease relapse as resistance develops. Treatment with immune-checkpoint inhibitors, either as…

RSS New England Journal of Medicine

  • Remote Patient Monitoring — Overdue or Overused? April 10, 2021
    The Covid-19 pandemic has challenged clinicians to find innovative ways to provide essential services while minimizing risks for themselves and their patients. These approaches increasingly leverage remote patient monitoring (RPM), using technology to support treatment for chronic conditions. As…
  • Race, Policing, and History — Remembering the Freedom House Ambulance Service April 10, 2021
    Americans protesting violent policing of Black communities are calling for law-enforcement budgets to be reallocated to community health services. Although such proposals are sometimes dismissed as naive or unrealistic, history provides an example of a transfer of power and resources from police to…
  • From Vaccine Nationalism to Vaccine Equity — Finding a Path Forward April 8, 2021
    The global effort to develop safe and effective Covid-19 vaccines has yielded remarkable results, owing in part to early, decisive investments in clinical discovery through efforts such as Operation Warp Speed. These achievements highlight the payoff of stable, long-term support of basic research…

RSS New England Journal of Medicine

  • Audio Interview: Antibody Responses to Natural Infection and Vaccination April 8, 2021
    The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
  • Vancomycin Infusion Reaction — Moving beyond "Red Man Syndrome" April 8, 2021
    In 1959, an article entitled "An Anaphylactoid Reaction to Vancomycin" hypothesized that vancomycin-induced histamine release from mast cells had clinical manifestations similar to those of anaphylaxis but less severe. The author named this reaction "Red Man Syndrome," reflecting the diffuse…
  • Ulceroglandular Tularemia April 8, 2021
    Figure 1.

RSS JAMA

RSS New England Journal of Medicine

  • Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma April 8, 2021
    First-line treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitors has been shown to provide benefits for patients with advanced renal cell carcinoma, but most patients have disease relapse as resistance develops. Treatment with immune-checkpoint inhibitors, either as…
  • A Step Ahead in Metastatic Renal Cell Carcinoma April 8, 2021
    Motzer et al. report in the Journal the efficacy and safety of pembrolizumab, an anti–programmed cell death 1 (PD-1) monoclonal antibody, used in combination with lenvatinib, an antiangiogenic drug (a vascular endothelial growth factor receptor [VEGFR] tyrosine kinase inhibitor), as compared with…
  • Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1 April 1, 2021
    Primary hyperoxaluria type 1 (PH1) is a rare, progressive genetic disease with debilitating and life-threatening clinical manifestations due to increased hepatic oxalate production. The metabolic defect in PH1 results from a deficiency of the liver-specific peroxisomal enzyme alanine–glyoxylate…

RSS New England Journal of Medicine

  • Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas April 10, 2021
    Malignant high-grade glioma accounts for 8 to 10% of pediatric brain tumors and is regularly fatal, with a rapid course. Survival rates have not improved in 30 years; the 3-year event-free survival among patients with newly diagnosed tumors who are treated with standard radiation and chemotherapy…
  • Case 10-2021: A 70-Year-Old Man with Depressed Mood, Unsteady Gait, and Urinary Incontinence April 8, 2021
    Presentation of Case. Dr. James W. Luccarelli (Psychiatry): A 70-year-old man with bipolar disorder was evaluated at this hospital because of depressed mood, suicidal ideation, and gait disturbance. The patient had a long history of depressive episodes, with two previous hospitalizations for…
  • Microbial Nourishment for Undernutrition April 7, 2021
    Hippocrates wrote "let food be thy medicine." Although access to nourishing food seems to be an obvious solution to the global health crisis of childhood undernutrition, the solution is not simple from a social or metabolic perspective, or even from the perspective of a microbiologist. To…

RSS JAMA

RSS New England Journal of Medicine

  • Closed Gastroschisis April 10, 2021
    In a male neonate born at 37 weeks of gestation, a narrow stalk of small bowel and proximal colon protruded through a 1.5-cm defect in the abdominal wall. A diagnosis of gastroschisis had been made antenatally on the basis of findings from prenatal ultrasonography. In the area where the bowel had…
  • "To Mitigate the Afflictions of the Human Race" — The Legacy of Dr. Rebecca Crumpler April 1, 2021
    For physicians in the 19th century, caring for sick infants and children still meant presiding at inevitable death after inevitable death. The organized public health struggle against infant mortality had not yet taken shape in 1883, when Dr. Rebecca Crumpler published A Book of Medical Discourses,…
  • The Political Nature of Sex — Transgender in the History of Medicine March 18, 2021
    On July 18, 2016, the final rule of the Department of Health and Human Services (HHS) implementing Section 1557 of the Affordable Care Act regarding gender nondiscrimination went into effect. Advocates were relieved that the law now included protections against discrimination in health care "on the…

RSS New England Journal of Medicine

  • A Step Ahead in Metastatic Renal Cell Carcinoma April 8, 2021
    Motzer et al. report in the Journal the efficacy and safety of pembrolizumab, an anti–programmed cell death 1 (PD-1) monoclonal antibody, used in combination with lenvatinib, an antiangiogenic drug (a vascular endothelial growth factor receptor [VEGFR] tyrosine kinase inhibitor), as compared with…
  • Sutimlimab in Cold Agglutinin Disease April 8, 2021
    Patients with cold agglutinin disease, a rare autoimmune hemolytic anemia, often have chronic anemia, profound fatigue, and acute hemolytic crisis. These patients may also have agglutination-mediated acrocyanosis and a higher risk of thromboembolism and early death. Cold agglutinin disease is…
  • Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma April 8, 2021
    First-line treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitors has been shown to provide benefits for patients with advanced renal cell carcinoma, but most patients have disease relapse as resistance develops. Treatment with immune-checkpoint inhibitors, either as…

RSS JAMA

  • Tumor-Infiltrating Lymphocytes for Prognostic Stratification in Nonmetastatic Colon Cancer April 8, 2021
    This Viewpoint discusses tumor-infiltrating lymphocytes and their potential role in prognostic stratification in patients with colorectal cancer.
  • Comparison of Therapy in Advanced Hepatocellular Carcinoma—Reply April 8, 2021
    In Reply We thank Xie et al for their interest in our recent systematic review and meta-analysis. We used progression-free survival (PFS) as reported in the included trials. Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 was used to assess the progression event in PFS in all refractory hepatocellular carcinoma trials except the RESORCE […]
  • Comparison of Therapy in Advanced Hepatocellular Carcinoma April 8, 2021
    To the Editor The treatment landscape of advanced hepatocellular carcinoma (HCC) has significantly changed in recent years. We applaud that Sonbol and colleagues conducted a systematic review and network meta-analysis providing a more systematic understanding of advanced HCC treatment options, irrespective of first-line or second-line setting. Herein, we raise several concerns.

RSS JAMA

RSS JAMA

RSS JAMA

RSS New England Journal of Medicine

  • Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas April 10, 2021
    Malignant high-grade glioma accounts for 8 to 10% of pediatric brain tumors and is regularly fatal, with a rapid course. Survival rates have not improved in 30 years; the 3-year event-free survival among patients with newly diagnosed tumors who are treated with standard radiation and chemotherapy…
  • Closed Gastroschisis April 10, 2021
    In a male neonate born at 37 weeks of gestation, a narrow stalk of small bowel and proximal colon protruded through a 1.5-cm defect in the abdominal wall. A diagnosis of gastroschisis had been made antenatally on the basis of findings from prenatal ultrasonography. In the area where the bowel had…
  • Ulceroglandular Tularemia April 8, 2021
    Figure 1.

RSS JAMA

RSS New England Journal of Medicine

  • Remote Patient Monitoring — Overdue or Overused? April 10, 2021
    The Covid-19 pandemic has challenged clinicians to find innovative ways to provide essential services while minimizing risks for themselves and their patients. These approaches increasingly leverage remote patient monitoring (RPM), using technology to support treatment for chronic conditions. As…
  • Closed Gastroschisis April 10, 2021
    In a male neonate born at 37 weeks of gestation, a narrow stalk of small bowel and proximal colon protruded through a 1.5-cm defect in the abdominal wall. A diagnosis of gastroschisis had been made antenatally on the basis of findings from prenatal ultrasonography. In the area where the bowel had…
  • Ulceroglandular Tularemia April 8, 2021
    Figure 1.

RSS New England Journal of Medicine

RSS JAMA

  • Consensus Framework for Treatment in Addiction and Obsessive-Compulsive–Related Disorders April 7, 2021
    This Viewpoint assesses a consensus framework for phenotyping and treatment selecting in addiction and obsessive-compulsive–related disorders.
  • Effects of a Blended Digital Therapy Targeting Reasoning on Paranoia April 7, 2021
    This randomized clinical trial investigates the effects and mechanisms of action of SlowMo, a digitally supported reasoning intervention, plus usual care compared with usual care only among individuals with clinical paranoia.
  • Errors in Text April 7, 2021
    In the Original Investigation titled “Accuracy Requirements for Cost-effective Suicide Risk Prediction Among Primary Care Patients in the US,” published online March 17, 2021, in JAMA Psychiatry, the word “variant” was changed to “variable” in 3 places in the Methods section in the Risk Assessment and Intervention subsection. In the third paragraph, the corrected sentence […]

RSS New England Journal of Medicine

  • Remote Patient Monitoring — Overdue or Overused? April 10, 2021
    The Covid-19 pandemic has challenged clinicians to find innovative ways to provide essential services while minimizing risks for themselves and their patients. These approaches increasingly leverage remote patient monitoring (RPM), using technology to support treatment for chronic conditions. As…
  • Audio Interview: Antibody Responses to Natural Infection and Vaccination April 8, 2021
    The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
  • Effect of Oxygen Therapy on Mortality in the ICU April 8, 2021
    Oxygen therapy is a key component of supportive care for patients who have hypoxemic respiratory failure and are being treated in the intensive care unit (ICU). Yet, although oxygen can be lifesaving for patients with severe hypoxemia, overzealous oxygen administration may be harmful. Furthermore,…

RSS New England Journal of Medicine

  • Sunken Nose April 8, 2021
    Figure 1.
  • Trial of Upadacitinib and Adalimumab for Psoriatic Arthritis April 1, 2021
    Upadacitinib is an oral, reversible Janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis. Adalimumab is a tumor necrosis factor α inhibitor used to treat rheumatoid arthritis and psoriatic arthritis. In one trial involving patients with rheumatoid arthritis, upadacitinib…
  • Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis March 25, 2021
    Atopic dermatitis is a common, chronic inflammatory skin disease associated with itch, pain, sleep disturbance, anxiety, depression, and increased health care utilization. When topical therapies are insufficient, treatment with systemic agents, including dupilumab and immunosuppressants, has been…

RSS New England Journal of Medicine

  • Closed Gastroschisis April 10, 2021
    In a male neonate born at 37 weeks of gestation, a narrow stalk of small bowel and proximal colon protruded through a 1.5-cm defect in the abdominal wall. A diagnosis of gastroschisis had been made antenatally on the basis of findings from prenatal ultrasonography. In the area where the bowel had…
  • Vestibular Schwannomas April 8, 2021
    Vestibular schwannomas account for 8% of all intracranial tumors and are the most common neoplasm of the cerebellopontine angle in adults. These tumors derive from myelinating Schwann cells of the vestibular division of the vestibulocochlear (eighth cranial) nerve. The term "vestibular schwannoma"…
  • Intrapericardial Colon April 1, 2021
    Figure 1.

RSS JAMA